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enclomiphene 50
(Androxal), in development by Repros Therapeutics Inc, is a non-steroidal estrogen
receptor antagonist that promotes gonadotropin-dependent testosterone secretion by
the testes. Enclomiphene constitutes the trans-stereoisomer of clomiphene citrate,
a drug that has been widely prescribed for several decades for the treatment of
female ovulatory dysfunction.
In clinical trials conducted to date,
enclomiphene tablets
demonstrated significant efficacy in the physiological restoration of
testosterone levels in males with secondary hypogonadism. The compound also
exhibited an unanticipated favorable effect on fasting plasma glucose; this result
has been accompanied by rapidly accumulating evidence from other researchers for a
bidirectional relationship between low serum testosterone and obesity/metabolic
syndrome (syndrome X) in men.  |
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